Description:

The Lurie Cancer Center Basic Research Seminar Series Presents:

Terminal Erythropoiesis and Its Dysregulation in Myeloid Neoplasms

Peng Ji, MD, PhD
Professor of Pathology (Experimental Pathology) and Pathology (Hematopathology)
Feinberg School of Medicine
Northwestern University

The Ji laboratory studies normal hematopoiesis and myeloid malignancies. Erythropoiesis, the process by which red blood cells mature, must be carefully regulated under steady state conditions and goes awry under stress/disease conditions. The Ji lab and colleagues recently showed important pathways that regulate normal erythropoiesis and how defects in these pathways induce anemia and ineffective erythropoiesis. This talk will highlight implications of this and further research and how dysregulation of erythropoiesis contributes to disease pathogenesis in myeloid neoplasms.