Northwestern Events Calendar

Jan
24
2023

Lurie Cancer Center Basic Research Seminar: Covalent DNA Modifications and Alternative DNA Conformations in Cellular Differentiation and Transformation

When: Tuesday, January 24, 2023
11:00 AM - 12:00 PM Central

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Cost: free

Contact: Jodi Johnson  

Group: Lurie Cancer Center Basic Science Programs

Category: Lectures & Meetings

Description:

The Lurie Cancer Center Basic Research Seminar Series presents:

Covalent DNA Modifications and Alternative DNA Conformations in Cellular Differentiation and Transformation

Vipul Shupka, PhD
Assistant Professor of
Cell and Developmental Biology
Feinberg School of Medicine
Northwestern University


The Shukla Lab is interested in understanding how cytosine modifications and alternative structural conformations in DNA regulate functional genomic states. In his talk, Dr. Shukla
will present their recent work about how the TET family of cytosine modifying enzymes regulate cellular differentiation and how loss of TET activity leads to an intriguing accumulation of G-quadruplexesand R-loops (alternative secondary DNA structures) during oncogenesis. He will also discuss recent work on how the alternative structural conformations in DNA can impact many established paradigms in genome biology and could serve as unique code for regulating genomic states.

All members of the Northwestern Medicine community are invited to attend.

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