Northwestern Events Calendar


M-I Dept. Seminar Series / Improving Vaccines by Modulating Hyperacute Antigen and Costimulatory Signals 

When: Tuesday, March 7, 2023
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings



Improving Vaccines by Modulating Hyperacute Antigen and Costimulatory Signals 


Sarah Sanchez, Graduate Student, Driskill Graduate Program (DGP), Lab of Dr. Pablo Penaloza-MacMaster


Our studies aim to understand how antigen and costimulation affect the immunogenicity of SARS-CoV-2 vaccines. To further understand how vaccine dosing affects vaccine-elicited immunity, we fractionated the initial priming dose of an adenovirus-based SARS-CoV-2 vaccine (low dose, LD), followed by a standard dose (SD) booster. We demonstrate that the LD/SD vaccine regimen leads to superior immune responses relative to an SD/SD regimen. Furthermore, we demonstrate time-dependent effects of costimulation on cellular responses elicited by mRNA vaccines, suggesting that delayed provision of 4-1BB costimulation could offer immunologic benefits.


Pablo Penaloza-MacMaster, PhD, Assistant Professor, Dept. of Microbiology-Immunology


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