Title:
Improving Vaccines by Modulating Hyperacute Antigen and Costimulatory Signals
Speaker:
Sarah Sanchez, Graduate Student, Driskill Graduate Program (DGP), Lab of Dr. Pablo Penaloza-MacMaster
Topic:
Our studies aim to understand how antigen and costimulation affect the immunogenicity of SARS-CoV-2 vaccines. To further understand how vaccine dosing affects vaccine-elicited immunity, we fractionated the initial priming dose of an adenovirus-based SARS-CoV-2 vaccine (low dose, LD), followed by a standard dose (SD) booster. We demonstrate that the LD/SD vaccine regimen leads to superior immune responses relative to an SD/SD regimen. Furthermore, we demonstrate time-dependent effects of costimulation on cellular responses elicited by mRNA vaccines, suggesting that delayed provision of 4-1BB costimulation could offer immunologic benefits.
Host:
Pablo Penaloza-MacMaster, PhD, Assistant Professor, Dept. of Microbiology-Immunology
Cynthia Naugles
(312) 503-0489
Email