Title:
Dynamic and Functional Changes to the Mammalian Ribosome During Poxvirus Infection
Speaker:
Natalia Khalatyan, Graduate Student, Driskill Graduate Program, Lab of Derek Walsh, PhD
Topic:
All viruses utilize the ribosomes of their cellular host for protein synthesis. Vaccinia virus (VacV), a prototypic poxvirus, induces host translational shut-off during infection yet the synthesis of viral proteins persists. The Walsh lab has previously identified a unique phosphorylation site on a ribosomal protein, RACK1, that maximizes translation of post-replicative viral mRNAs which harbor unusual 5' polyA-elements and allows for non-canonical modes of translation. My talk will discuss results from my research project that aims to determine if additional ribosomal proteins function in late stage VacV mRNA translation using a variety of genomic and proteomic approaches.
Host: Derek Walsh, PhD, Professor
Cynthia Naugles
(312) 503-0489
Email