When:
Tuesday, April 18, 2023
12:00 PM - 1:00 PM Central
Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Cynthia Naugles
(312) 503-0489
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Title:
Dynamic and Functional Changes to the Mammalian Ribosome During Poxvirus Infection
Speaker:
Natalia Khalatyan, Graduate Student, Driskill Graduate Program, Lab of Derek Walsh, PhD
Topic:
All viruses utilize the ribosomes of their cellular host for protein synthesis. Vaccinia virus (VacV), a prototypic poxvirus, induces host translational shut-off during infection yet the synthesis of viral proteins persists. The Walsh lab has previously identified a unique phosphorylation site on a ribosomal protein, RACK1, that maximizes translation of post-replicative viral mRNAs which harbor unusual 5' polyA-elements and allows for non-canonical modes of translation. My talk will discuss results from my research project that aims to determine if additional ribosomal proteins function in late stage VacV mRNA translation using a variety of genomic and proteomic approaches.
Host: Derek Walsh, PhD, Professor