Northwestern Events Calendar

Apr
18
2023

M-I Dept. Seminar Series / Dynamic and Functional Changes to the Mammalian Ribosome During Poxvirus Infection

When: Tuesday, April 18, 2023
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title:

Dynamic and Functional Changes to the Mammalian Ribosome During Poxvirus Infection

Speaker:

Natalia Khalatyan,  Graduate Student, Driskill Graduate Program, Lab of Derek Walsh, PhD

Topic:

All viruses utilize the ribosomes of their cellular host for protein synthesis. Vaccinia virus (VacV), a prototypic poxvirus, induces host translational shut-off during infection yet the synthesis of viral proteins persists. The Walsh lab has previously identified a unique phosphorylation site on a ribosomal protein, RACK1, that maximizes translation of post-replicative viral mRNAs which harbor unusual 5' polyA-elements and allows for non-canonical modes of translation. My talk will discuss results from my research project that aims to determine if additional ribosomal proteins function in late stage VacV mRNA translation using a variety of genomic and proteomic approaches.

Host: Derek Walsh, PhD, Professor

 

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