Title: Navigating landscapes of protein interaction specificity
Abstract: Proteins must form specific interactions to orchestrate important biological processes, yet how selective molecular recognition is encoded in protein sequence and structure is only partially understood. The Keating Lab has studied this problem for families of evolutionarily related proteins. In our recent work, we have focused on the interactions of structurally conserved protein domains with short linear motifs, which abound in the human proteome. I will discuss our studies of EVH1 domains and how their molecular recognition properties have evolved over hundreds of millions of years.
Reception to follow in Ryan Family Atrium (Lurie Building)
Amy E. Keating
Jay A. Stein Professor of Biology
Professor of Biological Engineering
Member, Koch Institute for Integrative Cancer Research
Head, MIT Department of Biology
Nate Will
(312) 503-4892
Email