Description:

Title:  Self-Nonself Discrimination  Conferred by Regulatory T Cell Specificity

Speaker: Peter Savage, PhD, Professor, Dept. of Pathology, The University of Chicago

Topic: 

During infection, in which both self- and pathogen-derived antigens are presented in an inflammatory environment permissive for T cell activation, how does the immune system selectively control self-reactive T cells while simultaneously enabling robust effector T cell responses to pathogen-derived antigens? In this study, we examine the hypothesis the regulatory T cells enforce this self-nonself discrimination by selectively constraining conventional T cells of shared specificity for the same self-peptide/MHC antigen.

Host: Booki Min, Phd, Professor, Dept. of Microbiology-Immunoloy