Description:

Seminar Title:

Identifying Immune Correlates of Protection and Determinants of Oncogenic Gammaherpesvirus Persistence Using Novel Animal Models 

Speaker:

Laurie T. Krug, Ph.D.
Stadtman Investigator
HIV and AIDS Malignancy Branch, NCI/CCR

Topic:

My laboratory uses animal models to identify and investigate virus-host interactions that are critical for chronic gammaherpesvirus infection and oncogenesis. I will report on the use of novel replication- and latency-defective viral vaccines that have identified immune correlates of protection from wild-type virus challenge in mice. My laboratory’s translational research program aims to apply pre-clinical animal models to develop effective interventions against cancers caused by Kaposi sarcoma herpesvirus. I will report on the establishment and characterization of Kaposi sarcoma patient-derived xenografts in immune-deficient mice. 

Host: Eva Gottwein, PhD, Associate Professor, Dept. of Microbiology-Immunology