Northwestern Events Calendar

May
28
2024

M-I Dept. Seminar / Lessons from Viruses: Novel Roles for Non-coding RNAs in the Regulation of Gene Expression

When: Tuesday, May 28, 2024
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, SQ Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Cynthia Naugles   (312) 503-0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title:  Lessons from Viruses: Novel Roles for Non-coding RNAs in the Regulation of Gene Expression

Speaker: Demián Cazalla, PhD, Department of Biochemistry, University of Utah School of Medicine

Topic:

Herpesvirus saimiri is an oncogenic herpesvirus that expresses seven Sm-class non-coding RNAs of unknown function called HSURs. We have found that one of these HSURs (HSUR2) base-pairs with mRNAs and recruits two cellular miRNAs to repress the expression of its target mRNAs. Using this mechanism, this virus can inhibit apoptosis in infected cells. These results reveal a new function for Sm-class RNAs as regulators of gene expression after pre-mRNA processing, and uncover a previously unrecognized strategy used by herpesviruses to rewire cellular pathways to escape apoptosis.

Host: Jesus Ortega, Graduate Student, Lab of Eva Gottwein, PhD, Dept. of Microbiology-Immunology

More Info Add to Calendar

Add Event To My Group:

Please sign-in