Description:

Abstract

Many chromatin regulators are essential for mammalian development, and mutations in chromatin regulators cause a variety of human developmental disorders. However, the developmental cell types and gene regulatory networks that rely on each chromatin regulator for their proper function are not well characterized. Together with collaborators at the Jackson Laboratory and UCSD, the Gorkin lab is leveraging mouse knockout lines lacking key epigenetic regulators linked to human disease in order to interrogate the effects of chromatin regulator loss during developmental at the molecular level, and with single-cell resolution. In this talk, Dr. Gorkin will give an update on the progress of this effort, and look ahead to future opportunities and challenges. 

About David Gorkin, PhD

Dr. David Gorkin is an Assistant Professor in the Department of Biology at Emory University. His lab studies the cell’s “epigenetic machinery”, seeking to understand how this machinery functions during development, and how its malfunction can contribute to disease. Dr. Gorkin received a Ph.D. in Human Genetics from the Johns Hopkins University School of Medicine, and completed a postdoctoral fellowship in Epigenomics at the University of California San Diego. Dr. Gorkin is also passionate about teaching and mentorship, which have been a consistent part of his professional development since he was a High School Science Teacher in New York City, prior to attending graduate school.