Description:

Won’t You Be My Neighbor: Proximity Proteomics to Uncover Mechanisms of Autism

Autism Spectrum Disorder (ASD) presents a complex challenge, characterized by its multifactorial nature and the identification of over 150 genes linked to increased risk. Despite these discoveries, our comprehension of the interrelationships among these genes and their direct contributions to ASD remains limited. The Soderling Lab has pioneered innovative techniques in genome engineering and proteomics to delve into the molecular underpinnings of ASD. Through this research, we have begun to unveil how ASD risk genes are interconnected and how they may influence the neuronal pathways implicated in autism. Specifically, our analysis of a critical pathway has highlighted a strategy to mitigate the neuronal abnormalities associated with a mutation recently discovered in patients. This approach not only advances our understanding of the genetic framework of ASD but also opens up new avenues for potential therapeutic interventions.

Scott Soderling, PhD
Professor and Chair of Cell Biology
Professor of Neurobiology
George Barth Geller, Distinguished Professor
Duke University