Title: Astrocytes, lactate and octopamine: Implications for Lewy Body Dementias Abstract: Octopamine is a well-established neurotransmitter in invertebrates involved in flight or fight responses. In mammals, its function has remained elusive given that its role was replaced by epinephrine. Our laboratory found a unique function of octopamine in the mammalian brain as a key metabolite diving the switch from protective to toxic astrocytes by harnessing their metabolism toward aerobic glycolysis. Pathological alterations in octopamine levels have been found in α-synucleinopathies such as Parkinson’s disease, as well as a range of psychiatric diseases including depression and bipolar disorder. Therefore, our work has therapeutic implications since we show that pharmacological modulation of octopamine pathway protects neurons against α-synuclein neurodegeneration.
Gabrila Caraveo Piso, PhD
Assistant Professor of Neurology (Movement Disorders) and Pharmacology
Melissa Daley
Email