Northwestern Events Calendar


Pharmacology Seminar Series | Daniel McGehee, PhD

When: Monday, June 24, 2024
3:00 PM - 4:00 PM CT

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Nate Will   (312) 503-4892

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings, Academic


Title: "Acetylcholine: An Endogenous Modulator of Descending Pain Control"


Although cholinergic agonists can relieve pain, the role of central cholinergic signaling in pain modulation has not been explored.  We recently identified an endogenous cholinergic circuit that regulates sensory and affective components of acute and chronic pain. Activating brainstem cholinergic input to the ventrolateral periaqueductal grey exerts profound analgesia through alpha7 nAChRs - an effect that persists despite opioid tolerance.

Guest Speaker: 

Daniel McGehee, PhD
Associate Professor of Pharmacology:
Member, Center of Pharmacogenomics    
University of Chicago


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