Description:

Tuesday, September 3, 2024

12:00 PM to 1:00 PM

IN-PERSON EVENT: 

McGaw Kellerman Classroom 

(McGaw-2-322)

Speaker:

Anthony Joudi, MD

Clinical Instructor, Transplant Pulmonology

Post-Doctoral Fellow, Singer Lab

Division of Pulmonary & Critical Care Medicine 

Northwestern

Abstract: Regulatory T cells (Tregs) are known to promote repair following epithelial damage in the setting of acute lung injury but can exhibit instability in inflammatory microenvironments. Natural Tregs (nTregs), while more stable, are relatively rare and difficult to expand; whereas induced Tregs (iTregs) are derived from more abundant CD4+ naïve T cells but exhibit more instability. My work focuses on the effect of maintenance DNA methylation, via the epigenetic regulator, Uhrf1, on the function and transcriptomic stability of iTregs in the context of influenza pneumonia. I will discuss the results of a series of in vitro and in vivo adoptive transfer experiments utilizing Foxp3-DTr mice infected with influenza A.