Description:

The Department of Biochemistry & Molecular Genetics presents:

Laura D Attardi, PhD
Catharine and Howard Avery Professor of the School of Medicine
Departments of Radiation Oncology and Genetics
Co-Director, Cancer Biology Program
Stanford University

Presentation:

“p53 governs cell state changes in LUAD suppression and therapeutic responses”

Abstract:

The TP53 gene is the most commonly mutated gene in human cancer, yet p53 remains undruggable in the clinic. In her laboratory, Dr. Attardi focuses on lung and pancreatic cancer to derive basic understanding into p53 function that will ultimately provide key clinical insights. In this presentation, she will focus on lung cancer, the leading cause of cancer deaths worldwide. She will discuss recent work from her laboratory in which they seek to understand the basis of how p53 suppresses lung cancer development. She will also describe  studies aimed at understanding the therapeutic side of p53 function, by defining mechanisms underlying p53-induced lung cancer regression.

Host: Dr. Lillian Eichner, Assistant Professor of Biochemistry and Molecular Genetics