Description:

Title: Carving Circuits from Correlative Connectomics

Speaker: Mariela Petkova, Harvard University

Abstract: Tracing the wiring diagram of a neural circuit is a powerful approach to test
computational models of brain function. Connectomics – the mapping of
neurons and their connections in the brain – poses formidable technical and
conceptual challenges. The former entails the acquisition and reduction of
vast amounts of electron microscopy image data to connectivity matrices,
achieved through multi-year, multi-team collaborative efforts. The latter
challenge is the problem of coarse-graining the connectivity matrices to
neural circuits which exhibit neural activity and function. I will describe both
challenges in the context of mapping the nervous system of a small
vertebrate – the larval zebrafish. In the same animal, we pair electron
microscopy with functional information from light microscopy to interrogate
neural circuit models for animal behavior from sensory inputs to motor output.

Zoom: https://northwestern.zoom.us/j/94241764594

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