The Department of Biochemistry & Molecular Genetics presents:
Danesh Moazed, PhD
Professor
Department of Cell Biology
Harvard Medical School and HHMI Investigator
Presentation:
"Epigenetic inheritance of heterochromatin”
Abstract:
The formation of heterochromatin and its faithful propagation during development and adult life play fundamental roles in silencing of transposons and lineage-specific cell identity genes. We have shown that heterochromatic histone H3K9 methylation and silencing can be epigenetically inherited during multiple cell divisions independently, and dependently, of DNA sequence. I will discuss the roles of RNA decay pathways and the recycling of parental histones during DNA replication in the inheritance process based on our identification of a conserved RNA degradation complex that localizes to heterochromatin and a conserved histone chaperone that coordinates parental histone transfer to newly synthesized DNA.
Host: Dr. Shannon Lauberth, Associate Professor of Biochemistry and Molecular Genetics
Linda Mekhitarian Jackson
(312) 503-5229
Email