Complex Systems Seminar: Keng-Hui Lin: "Investigating Mechanobiology in Vivo and in 3D"

This talk presents two complementary directions of my research in mechanobiology.

First, I will present our recent work to solve the century-old mystery on how highly regenerative animals such as zebrafish “know” how much tissue they lose. Our work showed that the zebrafish used the mechanical waves during the wound healing process to transmit the information of the amputation location. Second, I will describe the spherical microwells for 3D cell culture. The negative curved microenvironment affects cell behaviors such as cell cycle arrest of mesenchymal stem cells and their differentiation fate. Our preliminary suggests that the cell cycle arrest may be related to chromatin organization. Our studies highlight spherical microwells are an excellent platform to investigate 3D cell behaviors. 

Keng-Hui Lin, Research Fellow, Academia Sinica, Taipei

Host: John Marko

Add Event To My Group

Please sign-in