Title: The active reservoir as a therapeutic target to achieve HIV remission
Description: Although antiretroviral therapy (ART) effectively suppresses HIV replication, it is not a cure for HIV which persists in a long-lived reservoir of infected cells. This seminar will focus on the reservoir actively transcribing HIV – the so-called "active" HIV reservoir – which is an important therapeutic target for HIV cure and remission strategies given its contribution to chronic inflammation and its potential to elicit viral rebound upon ART interruption. The seminar will cover development and application of recent single-cell sequencing technologies to characterize the active HIV reservoir in blood and tissues of ART-suppressed people with HIV, and strategies to silence and eliminate this reservoir.
Amelia Crowe
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