Title: HIV assembly, maturation, and drug resistance
Description: Dr. Freed will describe key structural components of the immature HIV virus particle that assembles in HIV-infected cells and how this information is relevant to the development of HIV-1 maturation inhibitors and the role of IP6 in assembly, maturation, and infection. He will describe unconventional pathways through which HIV escapes from integrase strand transfer inhibitors and will provide evidence that these pathways operate not only in cell culture but also in people with HIV. He will discuss recent progress in the field in developing capsid inhibitors that may revolutionize HIV treatment and prevention. These studies highlight the connections between basic molecular virology, drug discovery, and lessons learned from drug resistance mechanisms.
Amelia Crowe
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